1. Staphylococcus aureus leads to a shift in the local immune reaction by the production of enterotoxins. These enterotoxins could reinforce the eosinophilic inflammation in different ways; amplification of the release of Th2 cytokines and IgE formation, and downregulation of T-regulatory cytokines may all contribute to the severe and chronic inflammatory process.

In der nasalen Mukosa führen Enterotoxine von Staphylococcus aureus zu einer Verstärkung der eosinophilen Inflammation über die Induktion von TH2-Zell-Zytokinen, die Ausbildung einer polyklonalen IgE-Antwort und die Herabregulation regulatorischer T-Zellen.